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KMID : 0370220070510030169
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Yakhak Hoeji
2007 Volume.51 No. 3 p.169 ~ p.173
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Effect of Morin on the Pharmacokinetics of Nifedipine in Rats
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Lee Chong-Ki
Choi Jun-Shik
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Abstract
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The aim of this study was to investigate the effect of morin on the pharmacokinetics of nifedipine in rats. The pharmacokinetic parameters of nifedipine were measured after the oral administration of nifedipine (5 mg/kg) in the presence or absence of morin (1.5, 7.5 and 15 mg/kg, respectively). Compared to the control groups, the presence of 7.5 mg/kg and 15 mg/kg of morin significantly (p<0.05) increased the area under the plasma concentration-time curve (AUC) of nifedipine by 48.5~68.2%, and the peak concentration (C[max]) of nifedipine by 59.9~84.2%. The absolute bioavailability(AB%) of nifedipine was significantly (p<0.05) increased by 21.5~24.5% compared to the control (14.5%). While there was no significant change in the time to reach the peak plasma concentration (T[max]) and the terminal half-life (T[1/2]) of nifedipine in the presence of morin. It might be suggested that morin altered disposition of nifedipine by inhibition of both the first-pass metabolism and p-glycoprotein (P-gp) efflux pump in the small intestine of rats. In conclusion, the presence of morin significantly enhanced the oral bioavailability of nifedipine, suggesting that concurrent use of morin or morin-containing dietary supplement with nifedipine should require close monitoring for potential drug interaction.
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KEYWORD
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nifedipine, morin, pharmacokinetics, p-glycoprotein, first-pass metabolism
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